Crystal structure of human TRF1 TRFH domain in complex with compound 40

Crystal structure of human TRF1 TRFH domain in complex with compound 40 Descriptor: 1,2-ETHANEDIOL, 4-[(3,5-dimethoxyphenyl)methoxy]naphthalene-1-sulfonic acid, CALCIUM ION, ... Authors: Casale, G, Le Bihan, Y.-V, van Montfort, R.L.M, Guettler, S. Deposit date: 2024-11-11 Release date: 2025-11-19 Last modified: 2025-12-03 Method: X-RAY DIFFRACTION (2.07 Å) Cite: Discovery of first-in-class inhibitors of the TRF1:TIN2 protein:protein interaction by fragment screening. Sci Rep, 15, 2025人类端粒重复结合因子1（TRF1）的TRFH结构域与化合物40复合物的晶体结构 成分描述：1,2-乙二醇、4-[(3,5-二甲氧基苯基)甲氧基]萘-1-磺酸、钙离子…… 作者：Casale G、Le Bihan Y.-V、van Montfort R.L.M、Guettler S. 入库日期：2024-11-11 发布日期：2025-11-19 最后修改日期：2025-12-03 实验方法：X射线衍射（分辨率2.07埃） 引用文献：通过片段筛选发现首个靶向TRF1:TIN2蛋白质-蛋白质相互作用的首创类抑制剂. Sci Rep, 15, 2025