Chromatin regulators as capacitors of inter-species expression variations

Alliance of Genome Resources2026-08-01 收录

染色质调控

跨物种表达差异

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https://www.yeastgenome.org/dataset/GSE23866 数据链接链接失效反馈

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We analyzed the genome-wide expression profiles of mutant strains of two yeast species in which eight different chromatin regulators and one transcription factor were deleted (one gene deleted in each strain)

METTL14 is a chromatin regulator independent of RNA N6-methyladenosine (ChIP-Seq). METTL14 is a chromatin regulator independent of RNA N6-methyladenosine (ChIP-Seq)

染色质调控

表观遗传学

METTL3 and METTL14 are two components that form the core heterodimer of the main RNA m6A methyltransferase complex (MTC, also known as m6A writer) that installs m6A. Surprisingly, depletion of METTL3

NIAID Data Ecosystem50

Cohesin and CTCF control chromosomal contact dynamics in living cells [4C-seq]. Cohesin and CTCF control chromosomal contact dynamics in living cells [4C-seq]

染色体构象动力学

染色质调控

Mammalian chromosomes are partitioned into topologically associating domains (TADs) by the loop-extrusion activity of cohesin that is blocked at specific DNA sites bound by CTCF. Chromosome structure

NIAID Data Ecosystem20

Table_2_A CTCF-Binding Element and Histone Deacetylation Cooperatively Maintain Chromatin Loops, Linking to Long-Range Gene Regulation in Cancer Genomes.xlsx

染色质调控

癌症基因组数据

BackgroundGenes spanning long chromosomal domains are coordinately regulated in human genome, which contribute to global gene dysregulation and carcinogenesis in cancer. It has been noticed that epige

NIAID Data Ecosystem10

Gene expression changes upon the mutation of individual residues of histone H3 and H4. Saccharomyces cerevisiae

组蛋白修饰定位

染色质调控

Nucleosome structure directly influences gene transcription. However, the function of each histone residue remains largely unknown. Here we profiled gene expression changes upon the mutation of indivi

NIAID Data Ecosystem30

Allele-Specific Chromatin Immunoprecipitation Studies Show Genetic Influence on Chromatin State in Human Genome

染色质调控

ChIP-chip

Several recent studies have shown a genetic influence on gene expression variation, including variation between the two chromosomes within an individual and variation between individuals at the popula

NIAID Data Ecosystem20

Chromatin regulators as capacitors of inter-species expression variations

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