Paired 2-tailed t test p values within each group for viraemia data.
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Since a vaccine is intended to provide immunological memory, the most important comparison is the follow-up vs. pre-treatment, although one could also make a case for post-treatment vs. pre-treatment. Values compared were averages for each subject during the time interval, computed using the database software. Sufficient power was present even in Group G, with only 6 members, to see a statistically significant effect during this interval. However, after Bonferroni correction for multiple hypothesis testing, only in Group F is significance maintained at the traditional 0.05 level. Values in parentheses are after Bonferroni correction for multiple hypothesis testing. In no case is there evidence for the efficacy of the vaccine regimen in lowering viraemia. (For the follow-up vs. pre-treatment comparison for Group J, n = 10 since one person was lost to follow-up.)
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2015-12-02



