Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease in Complex with N-[(1R)-2-(tert-butylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-N-(4-tert-butylphenyl)furan-2-carboxamide inhibitor.

Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease in Complex with N-[(1R)-2-(tert-butylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-N-(4-tert-butylphenyl)furan-2-carboxamide inhibitor. Descriptor: 3C-like proteinase, DIMETHYL SULFOXIDE, N-[(1R)-2-(tert-butylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-N-(4-tert-butylphenyl)furan-2-carboxamide Authors: Jacobs, J, Grum-Tokars, V, Zhou, Y, Turlington, M, Saldanha, S.A, Chase, P, Eggler, A, Dawson, E.S, Baez-Santos, Y.M, Tomar, S, Mielech, A.M, Baker, S.C, Lindsley, C.W, Hodder, P, Mesecar, A, Stauffer, S.R. Deposit date: 2011-12-13 Release date: 2013-01-16 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.96 Å) Cite: Discovery, Synthesis, And Structure-Based Optimization of a Series of N-(tert-Butyl)-2-(N-arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease. J.Med.Chem., 56, 2013

严重急性呼吸综合征冠状病毒（SARS-CoV）3CL蛋白酶与N-[(1R)-2-(叔丁基氨基)-2-氧代-1-(吡啶-3-基)乙基]-N-(4-叔丁基苯基)呋喃-2-甲酰胺抑制剂的复合物。
描述项：3C样蛋白酶、二甲基亚砜（DIMETHYL SULFOXIDE）、N-[(1R)-2-(叔丁基氨基)-2-氧代-1-(吡啶-3-基)乙基]-N-(4-叔丁基苯基)呋喃-2-甲酰胺
作者：Jacobs, J、Grum-Tokars, V、Zhou, Y、Turlington, M、Saldanha, S.A、Chase, P、Eggler, A、Dawson, E.S、Baez-Santos, Y.M、Tomar, S、Mielech, A.M、Baker, S.C、Lindsley, C.W、Hodder, P、Mesecar, A、Stauffer, S.R
提交日期：2011-12-13
发布日期：2013-01-16
最后修改日期：2024-02-28
实验方法：X射线衍射（分辨率1.96埃）
引用文献：《系列N-(叔丁基)-2-(N-芳基酰胺基)-2-(吡啶-3-基)乙酰胺（ML188）的发现、合成及基于结构优化：作为强效非共价小分子抑制剂对抗严重急性呼吸综合征冠状病毒3CL蛋白酶》，《药物化学杂志（J.Med.Chem.）》，第56卷，2013年