Molecular mechanisms of SpoT in biofilm formation in response to oxygen stress in Helicobacter pylori

This topic focuses on SpoT, using the WGCNA system to analyze the drug resistance mechanism of biofilm in Helicobacter pylori, that is, SpoT participates in the formation of biofilm under the oxygen stress of Helicobacter pylori by regulating NapA. To further explore the inducible factors of Helicobacter pylori forming biofilm on the surface of gastric mucosa, and whether reactive oxygen molecules can induce the formation of biofilm and its regulation mechanism, so as to provide clues for the treatment of Helicobacter pylori in vivo and the clearance of biofilm.