Sperm Small Non-Coding RNA sequencing of Testicular Germ Cell Tumors

Testicular germ cell tumors (TGCT) are the most common tumor in young adults of European ancestry. The high heritability and the constant increased incidence, which has doubled over the last 20 years, strongly suggest that both genetic and environmental factors are likely to shape the TGCT susceptibility. While genome wide association studies identified loci associated with TGCT suceptibility, the role played by environmental molecular vectors remains unclear. Evidence shows that sperm non-coding RNAs provide a good vision of the environmental stresses experienced by men. How TGCT impacts the sperm non-coding RNA profiles remains to be established. Here, we performed small RNA deep sequencing analysis in sperm of 25 men aged between 19 and 42, diagnosed with or without TGCT.