R-loops are trimeric nucleic acid structures that form when an RNA molecule hybridizes with its complementary DNA strand, displacing the opposite strand. These structures regulate transcription as wel

NIAID Data Ecosystem30

Epidermal cancer associated with expression of human papillomavirus type 16 E6 and E7 oncogenes in the skin of transgenic mice.

HPV致癌机制

转基因小鼠肿瘤模型

Certain "high-risk" anogenital human papillomaviruses (HPVs) have been associated with the majority of human cervical carcinomas. In these cancers, two papillomaviral genes, E6 and E7, are commonly ex

PubMed Central1993-06-15 更新20

Transcriptome analysis of Chd8 S62X heterozygote mutant and wild-type mice

发育疾病机制

大鼠转录组学

Autism spectrum disorders (ASD) are ~4-times more common in males than females, and CHD8 (a chromatin remodeler)-related ASD shows a strong male bias (~5:1), although the underlying mechanism remains

NIAID Data Ecosystem40

Interactome of the oncogenic deltaNp73alpha isoform in human papillomavirus 38 E6/E7-transformed keratinocytes

蛋白质相互作用

HPV致癌机制

DeltaNp73alpha is a major oncogenic isoform of tumor suppressor p73. We report deltaNp73alpha protein binding partners in the organelle and cytoplasmic compartments of a cellular model consisting of h

NIAID Data Ecosystem20

Transcription profiling of mouse ervical and skin tissues from HPV 16 E6 transgenic animals

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