Main characteristics of cluster randomized controlled trials for combination prevention of HIV transmission commissioned by PEPFAR.

Data as of 15 March 2012. aThe design of the intervention and plan of analysis for this trial are still being finalised. bStandard of care is ART for HIV-positive individuals with CD4<350 cells/µl or AIDS. cStandard of care is standard referral to MC and ART according to Tanzania guidelines (this will soon change from CD4<200 cells/µl to CD4<350 cells/µl, initially focusing on HIV-positive people with tuberculosis and pregnant women). dStandard of care is no home-based testing or home-based visit to facilitate linkage to ART. ART given according to country guidelines; standard referral to MC. eCumulative HIV incidence measured over the trial duration. CDC/HSPH, US Centers for Disease Control and Prevention/Harvard School of Public Health; HAART, highly active ART; JHU/USAID, Johns Hopkins University/United States Agency of International Development; PopART (HPTN 071), HIV Prevention Trials Network.