Enantioselective Cobalt-Catalyzed Reductive Cross-Coupling for the Synthesis of Axially Chiral Phosphine–Olefin Ligands

Transition-metal-catalyzed
enantioselective cross-electrophile
coupling reactions to construct C­(sp2)–C­(sp2) bonds remain a challenge. Herein, we report a general process
for the enantioselective Co-catalyzed reductive cross-coupling reaction
of o-(bromo)­arylphosphine oxide substrates and vinyl
triflates, delivering axially chiral phosphine oxide compounds with
good chemo- and enantioselectivity. A broad range of axially chiral
compounds was obtained with excellent enantioselectivities, and the
practical potential of this catalyst system was demonstrated by the
versatile formation of axially chiral ligands and other functional
atropisomers.