Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001913, tetragonal crystal from

Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001913, tetragonal crystal from Descriptor: (2R)-2-[(3-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)methyl]-3,3-difluoropropanoic acid, BROMIDE ION, CHLORIDE ION, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2020-11-02 Release date: 2021-07-07 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001913, tetragonal crystal form to be published

溃疡分枝杆菌Agy99（Mycobacterium ulcerans Agy99）来源的二氢叶酸还原酶（Dihydrofolate reductase, DHFR）与烟酰胺腺嘌呤二核苷酸磷酸（NADP）及抑制剂SDDC-0001913形成复合物的晶体结构，该复合物为四方晶系晶体，配体信息如下：(2R)-2-[(3-{3-[(2,4-二氨基-6-乙基嘧啶-5-基)氧基]丙氧基}苯基)甲基]-3,3-二氟丙酸、溴离子（BROMIDE ION）、氯离子（CHLORIDE ION）等。作者：西雅图传染病结构基因组学中心（Seattle Structural Genomics Center for Infectious Disease, SSGCID）。提交日期：2020-11-02；发布日期：2021-07-07；最后修改日期：2023-10-18。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.95 Å）。引用：溃疡分枝杆菌Agy99来源的二氢叶酸还原酶（DHFR）与NADP及抑制剂SDDC-0001913形成复合物的四方晶系晶体结构，待发表。