High-fat Diet Increase Heavy Metal Accumulation and Toxicity to Mice Liver and Kidney via Gut Microbiota

This study investigated the difference of high fat diet (HFD) and normal diet (ND) gut microbiota and their response and detoxification effects on As, Pb and Cd exposure. Results showed that when exposed to 100ppm As, Cd and Pb, HFD fed mice accumulated more heavy metals in liver and kidney along with more severe function damage than ND fed mice. Gut microbiota of ND and HFD was significantly different, and was also changed in response to As, Pb and Cd exposure. As enriched Bacteroides, Lactobacillus, Butyricimonas and Dorea; Cd enriched Faecoccus and Lactobacillus; Pb enriched Desulfovibrio, Plasmodium and Roseburia.