Crystal structure of human Aldose Reductase complexed with NADP and Fidarestat
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Crystal structure of human Aldose Reductase complexed with NADP and Fidarestat Descriptor: (2S,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE, CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: El-Kabbani, O, Darmanin, C, Schneider, T.R, Hazemann, I, Ruiz, F, Oka, M, Joachimiak, A, Schulze-Briese, C, Tomizaki, T, Mitschler, A, Podjarny, A. Deposit date: 2003-07-02 Release date: 2004-02-24 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (0.92 Å) Cite: Ultrahigh resolution drug design. II. Atomic resolution structures of human aldose reductase holoenzyme complexed with Fidarestat and Minalrestat: implications for the binding of cyclic imide inhibitors PROTEINS, 55, 2004
人源醛糖还原酶（Aldose Reductase）与烟酰胺腺嘌呤二核苷酸磷酸（NADP，NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE）及非达司他（Fidarestat）复合物的晶体结构
描述项：(2S,4S)-2-氨基甲酰基-6-氟-螺[色满-4,4'-咪唑烷]-2',5'-二酮、氯离子、烟酰胺腺嘌呤二核苷酸磷酸（NADP）……
作者：El-Kabbani, O、Darmanin, C、Schneider, T.R、Hazemann, I、Ruiz, F、Oka, M、Joachimiak, A、Schulze-Briese, C、Tomizaki, T、Mitschler, A、Podjarny, A
沉积日期：2003-07-02
发布日期：2004-02-24
最后修改日期：2024-04-03
实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率0.92埃）
引用文献：《超高分辨率药物设计 Ⅱ：人源醛糖还原酶全酶与非达司他及米那瑞司他复合物的原子分辨率结构：环酰亚胺类抑制剂结合机制的启示》，《PROTEINS》，第55卷，2004年
创建时间：
2003-07-02
