Brain region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice [bulk RNA-Seq]

To investigate the effect of Grin2a (a schizophrenia risk gene) and Grin2b (an autism spectrum disorder risk gene) loss of function on brain transcriptome. We performed unbiased transcriptomic profiling (bulk RNAseq analysis) in 5 brain regions and at four postnatal ages in Grin2a and Grin2b mutant mice. Comparative gene expression profiling analysis of RNA-seq data from prefrontal cortex (PFC), somatosensory cortex (SSC), hippocampus (HP), striatum (ST) and Thalamus (TH) at 2, 4, 12 and 20 weeks of age in Grin2a and Grin2b mutant mice. rna.