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Molecular rules for substrate-selective proteostasis modulation
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A unique ISR Program Determines Cellular Responses to Chronic Stress. Mus musculus
Integrated Stress Response (ISR) is a homeostatic mechanism induced by endoplasmic reticulum (ER) stress. With acute/transient ER stress, decreased global protein synthesis and increased uORF mRNA tra
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Proteome-wide changes in proteostasis in C. elegans models of longevity and age-related disease.
The balance between protein synthesis and protein breakdown is known as protein homeostasis (proteostasis) and loss of proteostasis is one of the Hallmarks of Aging. The latter is maybe best illustrat
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Source data underlying S5A–S5J Fig.
Organismal proteostasis is maintained by intercellular signaling processes including cell nonautonomous stress responses such as transcellular chaperone signaling (TCS). When TCS is activated upon tis
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Source data underlying Fig 3A–3D.
Organismal proteostasis is maintained by intercellular signaling processes including cell nonautonomous stress responses such as transcellular chaperone signaling (TCS). When TCS is activated upon tis
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The heat shock response relies on orthogonal mechanisms to maintain protein homeostasis in yeast
We globally analyzed the heat stress response (HSR) in yeast on the transcriptomic, tranlatomic and the proteomic level. The cells were stressed at 37 °C, 42 °C and 46 °C and the fractionated proteome
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