ORTODONTIK DAVOLASH VAQTIDA OG'IZ SUYUQLIGI TARKIBIDAGI YALLIG'LANISH MARKERLARINING DINAMIK O'ZGARISHI

Orthodontic treatment induces mechanical stress on periodontal tissues, leading to localized inflammatory responses. Recent studies indicate that inflammatory biomarkers such as interleukins (IL-1β, IL-6), tumor necrosis factor-alpha (TNF-α), and prostaglandins in saliva show dynamic changes during different stages of orthodontic tooth movement. Monitoring these salivary biomarkers provides a non-invasive method to assess the biological response, tissue remodeling, and treatment progress. Understanding the dynamic variations of these markers can improve personalized orthodontic care, optimize force application, and minimize adverse effects such as root resorption and periodontal damage [1, 2, 3].