Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) in complex with Genz-669178
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Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) in complex with Genz-669178 Descriptor: 5-(4-cyano-2-methyl-1H-benzimidazol-1-yl)-N-cyclopropylthiophene-2-carboxamide, DIHYDROOROTATE DEHYDROGENASE, FLAVIN MONONUCLEOTIDE, ... Authors: Rowland, P. Deposit date: 2014-02-12 Release date: 2014-04-30 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.98 Å) Cite: In Vitro Resistance Selections for Plasmodium Falciparum Dihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-Binding Site and Altered Growth. J.Biol.Chem., 289, 2014
恶性疟原虫（Plasmodium falciparum）二氢乳清酸脱氢酶（dihydroorotate dehydrogenase, DHODH）与Genz-669178的复合物 结构描述：5-(4-氰基-2-甲基-1H-苯并咪唑-1-基)-N-环丙基噻吩-2-甲酰胺、二氢乳清酸脱氢酶、黄素单核苷酸（flavin mononucleotide）…… 作者：Rowland, P. 沉积日期：2014-02-12 发布日期：2014-04-30 最后修改日期：2024-05-08 实验方法：X射线衍射法（分辨率1.98埃） 引用文献：《恶性疟原虫二氢乳清酸脱氢酶抑制剂的体外耐药筛选获得结合位点含多点突变且生长特性改变的突变体》，《生物化学杂志》，289卷，2014年
创建时间：
2014-02-12
