Effects on adult testis of Sertoli cell-specific ablation of miR-17-92 in mouse embryos. Effects on adult testis of Sertoli cell-specific ablation of miR-17-92 in mouse embryos

We induced specific deletion of miR-17-92 in Sertoli cells at the time of Amh expression in mouse embryos. We analyzed the effect of this deletion in the long term in adult testis. The transcriptome of mutant testis was consistently altered but do not produce a phenotype due to the testis homeostasis.