Translocation of Ezrin to plasma membrane

Ezrin is a member of the ezrin/radixin/moesin (ERM) family that acts as a linker between the plasma membrane and the actin cytoskeleton. Ezrin exists in a dormant, monomeric form in which its FERM/NERMAD and C-ERMAD domains are associated, masking membrane and F-actin binding regions. On production of PIP2, ezrin binds it, is recruited to the plasma membrane, and undergoes conformational changes unmasking the two binding sites.

Ezrin是ezrin/radixin/moesin（ERM）家族的成员，该家族充当质膜与肌动蛋白细胞骨架之间的连接蛋白。Ezrin以潜伏的、单体形式存在，其中其FERM/NERMAD和C-ERMAD结构域相互关联，掩盖了膜和F-肌动蛋白结合区域。在PIP2的产生过程中，Ezrin与之结合，被招募至质膜上，并经历构象变化，从而揭示了两个结合位点。