Identification of one plasmid harboring tmexCD1-toprJ1 in clinical Klebsiella pneumoniae
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Two clinical K. pneumoniae strains coharboring carbapenemase genes and novel tmexCD1-toprJ1 RND efflux pump were characterized here. The novel RND efflux pump gene cluster tmexCD1-toprJ1 coexisted with blaNDM-1 or blaKPC-2 in IncHI5-like and IncFII conjugative plasmids. This study highlights the emerging convergence of carbapenemase genes and tmexCD1-toprJ1 in typical MDR plasmids among clinical K. pneumoniae, which threatens treatments of CRKP infections. Epidemiology of such pathogens is warranted intensive investigations to evaluate the public health risk.
创建时间：
2021-02-19
