Candida glabrata Dihydrofolate Reductase complexed with 2,4-diamino-5-[3-methyl-3-(3-methoxy-5-phenylphenyl)prop-1-ynyl]-6-methylpyrimidine(UCP111D) and NADPH

Candida glabrata Dihydrofolate Reductase complexed with 2,4-diamino-5-[3-methyl-3-(3-methoxy-5-phenylphenyl)prop-1-ynyl]-6-methylpyrimidine(UCP111D) and NADPH Descriptor: 5-[(3R)-3-(5-methoxybiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Liu, J, Anderson, A. Deposit date: 2008-09-04 Release date: 2009-08-18 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.11 Å) Cite: Probing the active site of Candida glabrata dihydrofolate reductase with high resolution crystal structures and the synthesis of new inhibitors Chem.Biol.Drug Des., 73, 2009

光滑假丝酵母（Candida glabrata）二氢叶酸还原酶（Dihydrofolate Reductase）与2,4-二氨基-5-[3-甲基-3-(3-甲氧基-5-苯基苯基)丙-1-炔基]-6-甲基嘧啶（UCP111D）及烟酰胺腺嘌呤二核苷酸磷酸（NADPH）形成的复合物。描述符：5-[(3R)-3-(5-甲氧基联苯-3-基)丁-1-炔-1-基]-6-甲基嘧啶-2,4-二胺、二氢叶酸还原酶、烟酰胺腺嘌呤二核苷酸磷酸（DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE）。作者：Liu J、Anderson A。入库日期：2008年9月4日；发布日期：2009年8月18日；最后修改日期：2024年2月21日。实验方法：X射线衍射（分辨率2.11埃）。引用文献：《借助高分辨率晶体结构探究光滑假丝酵母二氢叶酸还原酶的活性位点并合成新型抑制剂》，《Chem.Biol.Drug Des.》，第73卷，2009年。