Giardia duodenalis strain:Be-2 Genome sequencing

Giardia lamblia, a single-celled eukaryotic parasite, is a major cause of waterborne infection throughout the world. G. lamblia infects a wide range of mammalian hosts and is subdivided into eight genetically well-defined assemblages; named A through H. Previously, molecular studies have revealed that most of the assemblages are associated with animal infection, whereas only AI, AII, and B are responsible for human infection. However, fragmented genomes and lack of comparative analysis within and between the assemblages impede the understanding of the molecular mechanisms of host specificity, and differential diseases outcome due to giardiasis. Thus, in the current study, we are conducting comparative genomics using assemblage A and assemblage B isolates derived by axenic culture utilizing a hybrid Nanopore/Illumina sequencing approach.