Vaccinia virus (VACV) encodes decapping enzyme D10 that suppresses gene expression by removing the protective 5’ cap off mRNAs, rendering them susceptible to degradation by cellular exonucleases. Here
5-methylcytosine (m5C) is emerging as an important epi-transcriptome modification involving RNA stability and translation efficiency in various biological processes. However, it remains unclear how m5
To investigate the function of TET2 as an mRNA m5C demethylase in the development of acute myeloid leukemia (AML), we conducted RNA bisulfite sequencing of mRNA samples enriched from AML cells carryin
aEach of the upstream 100–base messenger (mRNA) sequences (or 3′-untranslated regions) directly adjacent to the poly(A) tail starting position is unique, but all the mapped genomic sites (1.36 sites o
Medians of gene length L are calculated from the entire genomes set available on the NCBI database. mRNA half-lives t1/2 [18–21], elongation rates p [22–25] and initiation rates α [9, 26] are taken fr
