Conformational plasticity across phylogenetic clusters of RND multidrug efflux pumps and its impact on substrate specificity

AcrB_wt_apo_DDM: Single particle cryo-EM maps (.mrc) of trimeric AcrB wildtype in DDM (apo-state) AcrB_wt_apo_SP-ND: Single particle cryo-EM maps (.mrc) of trimeric AcrB wildtype in SaliPro-nanodiscs (apo-state) V612F_apo_DDM: Single particle cryo-EM maps (.mrc) of trimeric AcrB V612F variant in DDM (apo-state) V612F_apo_SP-ND: Single particle cryo-EM maps (.mrc) of trimeric AcrB V612F variant in SaliPro-nanodiscs (apo-state) V612W_apo_DDM: Single particle cryo-EM maps (.mrc) of trimeric AcrB V612W variant in DDM (apo-state) OqxB_apo_SP-ND: Single particle cryo-EM maps (.mrc) of trimeric OqxB wildtype in SaliPro-nanodiscs (apo-state) In total: AcrB wt DDM - 3 maps AcrB wt SP-ND - 16 maps V612F DDM - 3 maps V612F SP-ND - 4 maps V612W DDM - 6 maps OqxB wt SP-ND - 6 monomer maps + 1 trimer map in sum: 39 .mrc files