A proteomic study of dual-functional degrader in leukemia cell line

NIAID Data Ecosystem2026-05-02 收录

白血病细胞系蛋白质组学

靶向蛋白降解

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Here we present the proteomic study of WB156, which is a selective and dual-functional degrader against MDM2 and GSPT1, in leukemia cell line Molt4 and MV4;11.

创建时间：

2025-05-24

Mechanism of degrader-targeted protein ubiquitinability

靶向蛋白降解

泛素化机制

Small molecule degraders of disease-driving proteins offer a clinically proven modality with enhanced therapeutic efficacy and the potential to tackle previously undrugged targets. Thermodynamically s

NIAID Data Ecosystem50

Discovery of LL-K8-22: A Selective, Durable, and Small-Molecule Degrader of the CDK8-Cyclin C Complex

靶向蛋白降解

CDK8-cyclinC抗肿瘤靶点

The CDK8–cyclin C complex is an important anti-tumor target, but unlike CDK8, cyclin C remains undruggable. Modulators regulating cyclin C activity directly are still under development. Here, a series

Figshare2023-03-17 更新30

Discovery of a Highly Potent and Selective Degrader Targeting Hematopoietic Prostaglandin D Synthase via In Silico Design

靶向蛋白降解

计算机辅助药物设计

Targeted protein degradation by proteolysis-targeting chimera (PROTAC) is one of the exciting modalities for drug discovery and biological discovery. It is important to select an appropriate linker, a

NIAID Data Ecosystem30

Small-molecule degraders of SUMO1 induce the protein ubiquitination and degradation through CAPRIN1-CUL1-FBXO42 ubiquitin ligase for cancer therapySmall-molecule degraders of SUMO1 induce the protein ubiquitination and degradation through CAPRIN1-CUL1-FBXO42 ubiquitin ligase for cancer therapy

靶向蛋白降解

抗癌药物发现

Targeted protein degradation has been a long sought, but elusive, strategy for discovery of small-molecule degraders that activate E3 ubiquitin ligase-mediated ubiquitination and degradation of target

NIAID Data Ecosystem40

Discovery of Histone Deacetylase 8‑Specific Proteolysis-Targeting Chimeras with Anticancer Activity against Hematological Malignancies

靶向蛋白降解

肿瘤药物研发

Histone deacetylase 8 (HDAC8) has emerged as promising therapeutic target for several malignancies. In this study, we developed two series of cereblon (CRBN)-recruiting proteolysis-targeting chimeras

NIAID Data Ecosystem30

A proteomic study of dual-functional degrader in leukemia cell line

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