Endothelial Innate Immune Activation

The Endothelial Innate Immune Activation network depicts the causal mechanisms that describe acute response of healthy pulmonary endothelium to pro-inflammatory stimuli. These response mechanisms include production of the inflammatory chemokines, adhesion molecules and other mediators during endothelial cells activation leading to lung microvascular endothelial cells dysfunction. The network also includes causal mechanisms associated with angiogenic regulation by immune cells, including drivers of VEGF secretion and other related signaling pathways that crosstalk between the immune system and angiogenesis.