Impact of schizophrenia GWAS loci converge onto distinct pathways in cortical interneurons vs glutamatergic neurons during development. Impact of schizophrenia GWAS loci converge onto distinct pathways in cortical interneurons vs glutamatergic neurons during development

Genome binding/occupancy profiling was carried out by high throughput sequencing in human developmental cortical interneurons and developmental glutamatergic neurons derived from healthy control vs schizophrenia iPSCs Overall design: Open chromatin profiles (ATAC-seq assay) in human developmental cortical interneurons (MGE organoid) and glutamatergic neurons (CO organoid) derived from healthy control vs schizophrenia iPSCs