Dexamethasone effects on monocytes polarization

In this study, rat monocytes were separated and differentiated into macrophages by treating them with an optimized concentration of Dex. After confirming the differentiation of the macrophages, they were treated with antigens derived from rabbit red blood cells. The in vivo study evaluated the effects of autograft injection of cells treated with Dex, which contained antigens, on the modulation of innate and specific immune responses, as well as the induction of potential pathological lesions.本研究中，研究人员首先分离大鼠单核细胞，随后通过优化浓度的地塞米松（Dex）处理将其诱导分化为巨噬细胞。确认巨噬细胞分化完成后，研究人员采用兔红细胞来源的抗原对其进行处理。本体内实验评估了注射经地塞米松处理的携带有抗原的细胞的自体移植操作，对固有免疫与特异性免疫应答的调控作用，以及潜在病理损伤的诱导效应。