The raw data.

Sepsis remains a leading cause of morbidity and mortality among critically ill patients, particularly in resource‐limited settings where diagnostic capacity and therapeutic options are constrained. In this study, we aimed to identify clinical, laboratory, and treatment factors that independently predict in‐hospital mortality among adult sepsis patients admitted to a tertiary care intensive care unit (ICU) in the West Bank of Palestine. We conducted a retrospective cohort study of 326 adult patients (aged 18–80 years) admitted with sepsis to the medical ICU of a major tertiary referral hospital between January 2018 and December 2023. In‐hospital mortality was 41.4% (n = 135). Predictors of mortality were assessed using a multivariable logistic regression model. Multivariable logistic regression identified advancing age (OR 1.03 per year; 95% CI: 1.01-1.06; p = 0.010), cardiovascular disease (OR 2.66; 95% CI: 1.17-6.04; p = 0.020), elevated heart rate (OR 1.03 per beat/min; 95% CI: 1.01-1.04; p 2/FiO2 ratio (OR 1.00 per unit; 95% CI: 1.00-1.00; p = 0.006), and shorter ICU length of stay (OR 0.91 per day; 95% CI: 0.87-0.96; p