NHLBI TOPMed: Determining the Association of Chromosomal Variants with Non-PV Triggers and Ablation-Outcome in AF (DECAF)

The DECAF trial was conducted at the Texas Cardiac Arrhythmia Institute (TCAI) in 2013 in collaboration with the University of Texas at Austin. Four hundred consecutive AF patients undergoing catheter ablation were enrolled. All participants provided voluntary informed consents. Blood samples were collected before the ablation procedure and labeled with anonymous patient identifier. The researchers at UT Austin responsible for DNA extraction and genetic analysis were blinded about the clinical characteristics and identification of the study participants. AF cases included adults >18 years of age from both sex and all AF types.]]>
TOPMed Whole Genome Sequencing Methods: Freeze 8TOPMed Whole Genome Sequencing Methods: Freeze 9Exclusion criteria: Reversible causes of atrial arrhythmia such as hyperthyroidism, sarcoidosis, pulmonary embolism Unable to provide written informed consent ]]>
The study enrolled 400 AF patients undergoing catheter ablation at TCAI from December 2012 to September 2013. Genotyping was performed at UT Austin in April 2014 by researchers that were blinded to the phenotypes of the participating patients.]]>