Case-control study of the INSIG2 rs7566605 and PFKP rs6602024 variants in relation to overweight and obesity.

Data are number of subjects, divided into genotype groups (% in each group), frequencies of the minor allele (MAF) in percentages (95% CI) and odds ratio (OR) for the applied genetic model (95% CI). Differences in genotype distribution was evaluated using logistic regression, applying a recessive model (prec) for the INSIG2 rs7566605 variant (GG/GC vs. CC) and an additive model (padd) for the PFKP rs6602024 variant (GG vs. GA vs. AA). *In the combined study sample (where all four study groups, the Inter99 cohort, the ADDITION cohort, the SDC population-based and type 2 diabetes sample were included) p-values were adjusted for age, sex, and study group, whereas p-values in the **population-based Inter99 cohort were adjusted for age and sex. Controls were defined as BMI2 respectively.