Abscission couples cell division to embryonic stem cell fate
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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http://data.iscr.ac.cn/Article?id=0bdf023d96316abaf55891d14ce6017a
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资源简介：
This study was designed to investigate how the cell cycle phase impacts the kinetics of exit from pluripotency of mouse embryonic stem cells (mESC). mESC maintained in naïve medium conditions (2i) then sorted based on cell cycle phase before replating in self-renewing or differentiating media for 6hours, followed by single-cell RNA sequencing. Clustering of cells based on their expression of naive pluripotency genes indicate that cells that exit early in the cell cycle downregulate pluripotency genes faster than the bulk population. This study provides evidence that cell cycle phase is important in determining the timing of exit from pluripotency.
提供机构：
University of Cambridge
创建时间：
2022-02-20
