Kidney miRNA NHERF1 KO mice

The goal of the present study was to identify changes in miRNA levels during aging and the role of NHERF1 in regulation of miRNA expression in the kidneys. To address this aim, we analyzed differential expression of miRNAs in NHERF1-/- animals and their WT litermates from young and old mice.本研究旨在明确衰老过程中微小RNA（miRNA）水平的变化，以及钠氢交换调节因子1（NHERF1）在肾脏微小RNA表达调控中的作用。为实现该研究目标，我们对年轻及老年小鼠的NHERF1基因敲除（NHERF1-/-）动物及其野生型（WT）同窝对照小鼠的微小RNA差异表达情况进行了分析。