Predictive analysis of changes in protease activity associated with peptides differentially regulated in RA ¹.

1Frequency distribution analysis based on all peptides (n = 131). Mathematical calculations are based on the following parameter and calculations: occ(up) = Sum of all occurrences for each individual protease in the up-regulated peptides, occ(down) = Sum of all occurrences for each individual protease in the down-regulated peptides, N(up) = Total number of peptides being up-regulated, N(down) = Total number of peptides being down-regulated, % frequency(up) = (occ(up)/N(up)) * 100. % frequency(down) = (occ(down)/N(down)) * 100. % frequency difference ratio = | ((freq%(up) − freq%(down))/(freq%(up)+freq%(down)) * 100 |. Frequency scores = %freq * (occ(up)-occ(down)).