Comparison of human and bat metabolism.

Compared to other mammals, bats have increased longevity and higher resistance to cancer and infectious disease, in addition to their capacity for flight. This raises questions about bat metabolism. While prior studies have analyzed the metabolic requirements of flight, no study has integrated metabolomics, transcriptomics, and proteomics to characterize bat metabolism. In this work, we characterize fundamental differences in central metabolism between fibroblast cell lines from a black fruit bat (Pteropus alecto) and human, by analyzing multi-omics data via computational modelling of metabolic flux.