Changes in Gene Expression Profiles in Patients with Pulmonary Arterial Hypertension Associated with Scleroderma Treated with Tadalafil. Homo sapiens

The study looked at changes in gene expression profiles in subjects with Pulmonary Arterial Hypertension and Scleroderma (PAH-SSc) before and after treatment with Tadalafil. A total of ten subjects were enrolled and various clinical assessments including 6-minute walk tes, cardiac MRI and right heart catheterization were done in addition to gene expression study. Overall design: An open label study with subjects who have pulmonary arterial hypertension and scleroderma treated with tadalafil and their gene expression profiles were analyzed before and after tadalafil treatment