Ethoxysanguinarine ameliorates vascular remodeling by regulating TGF-ß1/Smad2/3 signaling pathway in Hypertension:An in vitro and in vivo approach

The goals of this study is to compare the differently expressed genes in abdominal aortaof WKY and SHR with or without Ethoxysanguinarine (ETH) treatment. The SHRs (n=12) were randomly divided into 2 groups: SHR, and SHR +ETH (3.5mg/kg/d) groups (n=6 for each group). WKY rats (n=6) were set as control. Rats in WKY and SHR groups were intragastrically with double distilled water (dd H2O), while rats in SHR + ETH (3.5mg/kg/d) group were intragastrically with 3.5 mg/kg/d of ETH for 10 weeks. Then the vascular vessel tissues were used to identify differentially expressed genes among different groups. Overall design: RNA sequencing was performed with abdominal aortaof rats in 3 groups: WKY, SHR, SHR +ETH (3.5mg/kg/d) treated (n=6 for each group) to identify the differently expressed genes and related pathway.