The Cancer Genome Atlas Breast Invasive Carcinoma Collection (TCGA-BRCA)

The Cancer Genome Atlas Breast Invasive Carcinoma (TCGA-BRCA) data collection is part of a larger effort to build a research community focused on connecting cancer phenotypes to genotypes by providing clinical images matched to subjects from The Cancer Genome Atlas (TCGA). Clinical, genetic, and pathological data resides in the Genomic Data Commons (GDC) Data Portal while the radiological data is stored on The Cancer Imaging Archive (TCIA). Matched TCGA patient identifiers allow researchers to explore the TCGA/TCIA databases for correlations between tissue genotype, radiological phenotype and patient outcomes. Tissues for TCGA were collected from many sites all over the world in order to reach their accrual targets, usually around 500 specimens per cancer type. For this reason the image data sets are also extremely heterogeneous in terms of scanner modalities, manufacturers and acquisition protocols. In most cases the images were acquired as part of routine care and not as part of a controlled research study or clinical trial.

癌症基因组图谱乳腺浸润性癌（TCGA-BRCA）数据集是一项更大规模研究计划的组成部分，该计划旨在构建一个聚焦癌症表型与基因型关联的研究共同体，通过为癌症基因组图谱（The Cancer Genome Atlas, TCGA）的受试者匹配临床影像，实现二者的关联研究。临床、遗传与病理数据存储于基因组数据共享（Genomic Data Commons, GDC）数据门户，而放射学影像数据则存储于癌症影像档案（The Cancer Imaging Archive, TCIA）。匹配的TCGA患者标识符可帮助研究人员检索TCGA/TCIA数据库，以探索组织基因型、放射学表型与患者预后之间的关联。为达成样本招募目标（通常每种癌症类型招募约500份样本），TCGA的组织样本采自全球多个采集站点。正因如此，该影像数据集在扫描设备类型、制造商及采集协议方面均呈现极强的异质性。在大多数情况下，这些影像均为常规诊疗过程中采集所得，而非受控研究或临床试验的一部分。