Effect of metformin on chromatin accessibility in lung cancer cells
收藏NIAID Data Ecosystem2026-03-11 收录
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资源简介：
The DNA regions whose chromatin accessibility was significantly altered by metformin were investigated in lung cancer cells by ATAC-seq. Metformin decreased chromatin accessibility in 159 regions but increased it in 124 sites. Most regions were outside of gene promoters defined as TSS ± 3kb. The most suppressed region was 4,667bp downstream of CHAC1, and the most enhanced site was 15,111bp downstream of ERRFI1. Overall design: Examination of the chromatin accessibility in H1299 cells treated with or without 5mM metformin.
创建时间：
2019-11-29
