Transcriptomic analysis of human astrocytes in vitro reveals hypoxia-induced mitochondrial dysfunction, modulation of metabolism and dysregulation of the immune response

Changes in the transcriptomic profile of the Sciencell human astrocytes, after hypoxia treatment were compared to control cells receiving no treatment, to identify differentially expressed genes and pathways. This study is to understand how hypoxia affects astrocytes and how this might reflect changes induced in circumstances such as ischaemia. The aim of this study was to carry out gene expression profiling of human astrocytes in response to hypoxia. It is thought that this may elucidate pathological processes that can be manipulated through therapeutic intervention to ultimately prevent neurodegeneration. Therefore, the current study performed a detailed characterization of the astrocyte gene expression profile in response to hypoxia in vitro, extending on previous reports and identifying novel candidate gene expression changes.