Top 10 significantly enriched KEGG pathways.

BackgroundColorectal cancer (CRC) is a leading cause of global cancer-related mortality, necessitating the identification of novel therapeutic targets. Integrating genetic and transcriptomic data may reveal key molecular drivers of CRC progression and treatment opportunities.MethodsWe performed a multiomics analysis combining genome-wide association study (GWAS) data (p ResultsIntegration of GWAS and RNA-seq revealed that 24 CRC-associated genes, including PYGL, SMAD7, and TCF7L2, are involved in tumor metabolism and Wnt/TCF signaling. Survival analysis revealed that five genes (CDKN2B, BOC, METRNL, etc.) were significantly correlated with OS, RFS, and PPS. Ten small-molecule candidates targeting PYGL exhibited high binding affinity, suggesting their therapeutic potential.ConclusionThis study identified CRC-linked genes through GWASs and transcriptomics, highlighting their prognostic and druggable relevance. Computational drug repurposing pinpoints PYGL inhibitors as promising candidates, offering a translational framework for CRC therapy development.