Cryo-EM structure of hZnT7-Fab complex in zinc-unbound state, determined in heterogeneous conformations- one subunit in an inward-facing and the other in an outward-facing conformation

Cryo-EM structure of hZnT7-Fab complex in zinc-unbound state, determined in heterogeneous conformations- one subunit in an inward-facing and the other in an outward-facing conformation Descriptor: Heavy chain of YN7114-08 Fab, Light chain of YN7114-08 Fab, Zinc transporter 7 Authors: Han, B.B, Inaba, K, Watanabe, S. Deposit date: 2023-04-28 Release date: 2023-09-20 Last modified: 2025-07-02 Method: ELECTRON MICROSCOPY (2.79 Å) Cite: Cryo-EM structures of human zinc transporter ZnT7 reveal the mechanism of Zn 2+ uptake into the Golgi apparatus. Nat Commun, 14, 2023本数据集为无锌结合状态下人源锌转运蛋白7-Fab（hZnT7-Fab）复合物的冷冻电镜（Cryo-EM）结构，该结构解析自异质构象——其中一个亚基处于内向构象，另一亚基处于外向构象。 描述物：YN7114-08 抗原结合片段（Fab）重链、YN7114-08 抗原结合片段（Fab）轻链、锌转运蛋白7 作者：Han B.B.、Inaba K、Watanabe S 沉积日期：2023-04-28 发布日期：2023-09-20 最后修改日期：2025-07-02 解析方法：电子显微镜（2.79 Å） 引用文献：人源锌转运蛋白ZnT7的冷冻电镜结构揭示了Zn²⁺摄取进入高尔基体的机制，《自然-通讯》（Nat Commun），第14卷，2023年