X-ray structure of a Drosophila dopamine transporter with NET-like mutations (D121G/S426M/F471L) in milnacipran bound form

X-ray structure of a Drosophila dopamine transporter with NET-like mutations (D121G/S426M/F471L) in milnacipran bound form Descriptor: (1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenyl-cyclopropane-1-carboxamide, Antibody fragment 9D5 Light chain, Antibody fragment 9D5 heavy chain, ... Authors: Shabareesh, P, Mallela, A.K, Joseph, D, Penmatsa, A. Deposit date: 2020-03-04 Release date: 2021-02-17 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (3.11 Å) Cite: Structural basis of norepinephrine recognition and transport inhibition in neurotransmitter transporters. Nat Commun, 12, 2021

携带类去甲肾上腺素转运体（norepinephrine transporter, NET）突变（D121G/S426M/F471L）的果蝇多巴胺转运体（Drosophila dopamine transporter）结合米那普仑（milnacipran）的X射线晶体结构。组分信息：(1R,2S)-2-(氨甲基)-N,N-二乙基-1-苯基环丙烷-1-甲酰胺，抗体片段9D5轻链，抗体片段9D5重链等。作者：Shabareesh P、Mallela A.K、Joseph D、Penmatsa A。提交日期：2020-03-04，发布日期：2021-02-17，最后修改日期：2024-10-09。实验方法：X射线衍射，分辨率3.11埃（Å）。引用文献：《神经递质转运体去甲肾上腺素识别与转运抑制的结构基础》，发表于《自然-通讯》（Nature Communications, Nat Commun），2021年，第12卷。