Lepr-Tdtomato小鼠做为受体小鼠，经尾静脉移植AML 细胞，监测外周血至发病晚期，胶原酶消化AML 与CTRL 小鼠的后肢骨，分选Tdtomato 阳性细胞，分选得到的AML小鼠与正常小鼠Lepr-Tdtomato细胞交予诺禾致源公司，进行10X Genomics单细胞转录组的建库和测序，以得到这群细胞的异质性及其在白血病下细胞亚群变化的转录数据。

国家人口健康科学数据中心130

Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia (ERRBS)

表观遗传学

白血病研究

Aging is associated with functional decline of hematopoietic stem cells (HSC) as well as an increased risk of myeloid malignancies. We performed an integrative characterization of epigenomic and trans

干细胞与再生医学数据中心2022-02-20 更新80

microRNA expression in CUTLL1 cells

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