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Emergent metastatic heterogeneity of primary tumor cells is restricted by the Ig-transmembrane protein VSIG III

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NIAID Data Ecosystem2026-03-12 收录
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Our study prompeted us to assign, through spiked single cell RNAseq, metastatic function to transcriptomic cluster of colon cancer cells. Interactions between clones also uncover a restrictive anti metastatic influence that act intrinsically and non-cell automomously. We identify VSIG1 as critical mediator of this influence. RNAseq of 2 clones derived from heterogeneous primary Colon Cancer cell culture, in triplicates

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2020-11-09
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