RMC-5552 in complex with mTORC1 and FKBP12

RMC-5552 in complex with mTORC1 and FKBP12 Descriptor: (3S,5R,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,30R,34aS)-5,9,27-trihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-5,6,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-octadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,11,28,29(4H,31H)-tetrone, 1-[6-{[(3M)-4-amino-3-(2-amino-1,3-benzoxazol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl}-3,4-dihydroisoquinolin-2(1H)-yl]-3-hydroxypropan-1-one, Peptidyl-prolyl cis-trans isomerase FKBP1A, ... Authors: Tomlinson, A.C.A, Yano, J.K. Deposit date: 2022-10-11 Release date: 2022-12-28 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (2.86 Å) Cite: Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors. J.Med.Chem., 66, 2023RMC-5552与雷帕霉素靶蛋白复合物1（mTORC1）、FK506结合蛋白12（FKBP12）形成的三元复合物 描述符：(3S,5R,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,30R,34aS)-5,9,27-三羟基-3-{(2R)-1-[(1S,3R,4R)-4-羟基-3-甲氧基环己基]丙-2-基}-10,21-二甲氧基-6,8,12,14,20,26-六甲基-5,6,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-十八氢-3H-23,27-环氧并吡啶并[2,1-c][1,4]氧杂环三十三烷-1,11,28,29(4H,31H)-四酮，1-[6-{[(3-甲基)-4-氨基-3-(2-氨基-1,3-苯并恶唑-5-基)-1H-吡唑并[3,4-d]嘧啶-1-基]甲基}-3,4-二氢异喹啉-2(1H)-基]-3-羟基丙-1-酮，肽基脯氨酰顺反异构酶FKBP1A（又称FKBP12）…… 作者：Tomlinson, A.C.A、Yano, J.K. 寄存日期：2022-10-11 发布日期：2022-12-28 最后修改日期：2024-06-19 检测方法：电子显微镜（分辨率2.86 Å） 引用文献：《RMC-5552：一种治疗mTORC1激活肿瘤的选择性双位阻抑制剂的发现》，《药物化学杂志》（J.Med.Chem.），2023年，第66卷