Long noncoding RNA MALAT1 activates HIV-1 infection by detaching polycomb repressive complex 2 from binding to the promoter of long terminal repeat for mediating epigenetic silencing. Long noncoding RNA MALAT1 activates HIV-1 infection by detaching polycomb repressive complex 2 from binding to the promoter of long terminal repeat for mediating epigenetic silencing

Accumulating data have emphasized the critical role of long noncoding RNAs (lncRNAs) in regulating HIV-1 replication. LncRNAs may repress or active HIV-1 replication and latency through regulating different cellular machineries. Our RNA-Sequencing (RNA-Seq) revealed the up-regulation of MALAT1 (metastasis-associated lung adenocarcinoma transcript 1), a lncRNA being mainly described in cancer cells that associates with cancer pathogenesis, in HIV-1 infected CD4+ T cells Overall design: HIV-1NL4-3-infected and uninfected CD4+ T cells, sequenced on Hiseq X10 sequencer (Illumina)