Durable Response of Enzalutamide-resistant Prostate Cancer to Supraphysiological Testosterone Is Associated with a Multifaceted Growth Suppression and Impaired DNA Damage Response Transcriptomic Program in Patient-derived Xenografts. Durable Response of Enzalutamide-resistant Prostate Cancer to Supraphysiological Testosterone Is Associated with a Multifaceted Growth Suppression and Impaired DNA Damage Response Transcriptomic Program in Patient-derived Xenografts

The study aims to determine SPT effect on the CRPC growth and molecular alterations using LuCaP PDX CRPC models. Overall design: RNA sequencing of castration-resistant PC (CRPC) patient-derived xenograft (PDX) lines using Illumina TruSeq Library prep and sequenced on Illumina HiSeq 2500.