Comparison of the kidney transcriptome of 28 days old principal cell-specific Tsc1 knockout (Tsc1f/f/Aqp2 Cre) vs wild-type (WT) mice

Tuberous sclerosis complex is a genetic disorder that affects multiple organs. In the kidney, it presents as hamartomas and cysts. The epithelium of TSC renal cysts is primarily composed of A-intercalated cells. In these studies, we compared the renal transcriptomes of 28 days old principal cell-specific Tsc1 knockout (Tsc1f/f/Aqp2 Cre; Tsc1 KO) and WT mice. The kidney transcriptome of principal cell-specific C57BL/6 Tsc1 knockout mice (Tsc1f/f/Aqp2 Cre) vs WT C57BL/6 at 28 days of age were compared.