X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP

Protein Data Bank Japan2023-08-30 更新2026-03-21 收录

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X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP Descriptor: 2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE, ADENOSINE-5'-TRIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, ... Authors: Ohren, J.F, Pavlovsky, A.G. Deposit date: 2007-03-14 Release date: 2007-10-02 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.8 Å) Cite: 4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase. J.Med.Chem., 50, 2007

人丝裂原活化蛋白激酶激酶1（mitogen-activated protein kinase kinase 1, MEK1）与配体及MgATP形成复合物的X射线晶体结构。数据集描述项：2-[(4-乙炔基-2-氟苯基)氨基]-3,4-二氟-N-(2-羟基乙氧基)苯甲酰胺、三磷酸腺苷（adenosine-5'-triphosphate）、双特异性丝裂原活化蛋白激酶激酶1（Dual specificity mitogen-activated protein kinase kinase 1）等。作者：Ohren, J.F.、Pavlovsky, A.G. 存放日期：2007-03-14 发布日期：2007-10-02 最后修改日期：2023-08-30 研究方法：X射线衍射（分辨率2.8 Å）引用文献：《4-苯胺基-5-甲酰胺基-2-吡啶酮类衍生物作为丝裂原活化蛋白激酶激酶的非竞争性抑制剂》，《药物化学杂志》（J.Med.Chem.），2007年，第50卷

创建时间：

2007-03-14