Expression data from lupus NZB/W and NZW/BXSB mouse prenephritic kidneys. Mus musculus

We defined the shared and unique features of systemic lupus erythematosus (SLE) nephritis in 2 mouse models of proliferative renal disease. We identified shared inflammatory mechanisms of SLE nephritis that can be therapeutically targeted. Some common mechanisms are shared with non-immune-mediated renal diseases, suggesting that new strategies to prevent tissue hypoxia and remodeling may be useful in SLE nephritis. Overall design: RNA from whole kidneys was extracted and processed for hybridization on Affymetrix microarrays.